EDUCATION AND RESEARCH EXPERIENCE
- 1978 - 1982 Xiamen University (China), BSc in Chemistry 1982
- 1983 – 1984 Universite de Montpellier II (France), DEA in Organic Chemistry 1984
- 1984 – 1987 L’institut de Chimie des Substances Naturelles, CNRS (supervisor: Prof. H.-P. Husson) and Universite de Paris-Sud (Orsay) (France) Ph.D. in Organic Chemistry 1987
- 1988 - 1990: Shanghai Institute of Organic Chemistry, CAS, Postdoctoral Fellow with the late Prof. W. S. Zhou
- 1990 – 1993 Xiamen University (China), Associate Professor
- 1993 - Xiamen University: Professor of Chemistry
RESEARCH INTERESTS
Synthetic Methodology; Asymmetric Synthesis; Asymmetric Synthesis of Natural Products and Drugs (Alkaloids, Pheromones, etc).
HONORS AND AWARDS
- National Scientific Fund for Distinguished Young Investigator (1996)
- Hong Kong Qiu Shi Scientific & Technological Foundation Award for Distinguished Young Scientist (1997)
- Fellow of RSC (since 2006)
- Minjiang Chair Professor (since 2006)
- Award for Creativity in Organic Synthesis by the Organic Chemistry Division, Chinese Chemical Society (2007)
- Asian Core Program Lectureship Award (2009, Thailand, supported by JSPS)
RESEARCH AND ACADEMIC EMPLOYMENT
- Council Member of the Chinese Chemical Society
- Vice Chairman of the Organic Chemistry Division, Chinese Chemical Society (CCS, 2011-2016).
- Member of the Organic Synthesis Division, Chinese Chemical Society (2001-)
- Member of the Chemical Biology Division, Chinese Chemical Society (2007-)
- On the editorial board of 2 International Journals:
Current Organic Synthesis (advisory editorial board )
The Open Organic Chemistry Journal
- On the editorial board of 6 Chinese Journals:
Science China Chemistry
Acta Chimica Sinica
Chinese Chemical Letters
Youji Huaxue (Chinese Journal of Organic Chemistry);
Natural Products Research & Development;
- J. of Xiamen Univ.
- 2003- Dean of the College of Chemistry and Chemical Engineering, Xiamen University
REPRESENTATIVE PUBLICATIONS AND BOOKS
- Enantioselective Total Syntheses of (-)-FR901483 and (+)-8-epi-FR901483, 2013J. Org. Chem.
- SmI2-Mediated Intermolecular Coupling of Lactam N-α -Radicals with Activated Alkenes: Asymmetric Synthesis of 11-Hydroxylated Analogues of the Lead Compounds CP-734432 and PF-04475270 ,2013, J. Org. Chem.
- The Total Synthesis of (-)-Sessilifoliamide J ,2013J. Org. Chem.
- Toward the Total Synthesis of Haliclonin A: Construction of a Tricyclic Substructure ,2013, Chem. Eur. J.
- Direct Transformation of Secondary Amides into Secondary Amines: Triflic Anhydride Activated Reductive Alkylation ,2012, Angew. Chem., Int. Ed
- The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK ,2012, Nature Chemical Biology
- A Formal Enantioselective Total Synthesis of FR901483, 2012 ,Org. Lett.
- SmI2-Mediated Coupling of Nitrones and tert-Butanesulfinyl Imines with Allenoates: Synthesis of β-Methylenyl-g -lactams and Tetramic Acids, 2012, Org. Lett.
- Divergent Enantioselective Synthesis of Rigidiusculamide B and the Proposed Structure of Rigidiusculamide A: Revision of the Relative Stereochemistry of Rigidiusculamide A ,2012 ,Chem. Asian J.
- Concise Asymmetric Total Synthesis of 9-epi-Sessilifoliamide J ,2011, Org. Lett.
- Asymmetric Synthesis of 5-Alkyl Tetramates and the Asymmetric Total Synthesis of Marine Natural Product Belamide A ,2011 ,Chem. Eur. J.
- Asymmetric Vinylogous Mannich Reactions: A Versatile Approach to Functionalized Heterocycles, 2011 ,Org. Lett.
- SmI2-Mediated Radical Cross-Couplings of α-Hydroxylated Aza-Hemiacetals and N,S-Acetals with α,β-Unsaturated Compounds: Asymmetric Synthesis of (+)-Hyacinthacine A2, (-)-Uniflorine A, and (+)-7-epi-Casuarine, 2011, J. Org. Chem.
- A New Method for the Construction of the Hydroxylated Tropane Skeleton: Enantioselective Synthesis of (-)-Bao Gong Teng A, 2011 ,Chem. Commun.
- Direct, One-pot Sequential Reductive Alkylation of Lactams/Amides with Grignard and Organolithium Reagents via Lactam/Amide Activation ,2010 ,Angew. Chem., Int. Ed
- Efficient and chemoselective alkylation of amines/amino acids using alcohols as alkylating reagents under mild conditions ,2010 ,Chem. Commun.
- Versatile One-pot Reductive Alkylation of Lactams/ Amides via Amide Activation: Application to the Concise Syntheses of Bioactive Alkaloids (±)-Bgugaine, (±)-Coniine, (+)-Preussin, and (–)-Cassine, 2010 ,Chem. Eur. J.
- Studies towards an Enantioselective Total Synthesis of Sarain A: A Concise Asymmetric Construction of the Diazatricyclic Core ,2010, Chem. Eur. J.
- NSAID Sulindac and Its Analog Bind RXRα and Inhibit RXRα-Dependent AKT Signaling ,2010 ,Cancer Cell
- The first enantioselective synthesis of cytotoxic marine natural product palau’imide and assignment of its C-20 stereochemistry, 2010 ,Chem. Commun.
- A Flexible Approach to 2-Hydroxyalkyl 3-hydroxy-2- pyrrolidinone Derivatives: Concise Asymmetric Syntheses of (+)-1-Epi-Castanospermine and (+)-Castanospermine, and 7-Deoxy-6-epi-CAS, 2010, Chem. Eur. J. ,德国
- A Concise and Divergent Approach for the Asymmetric Syntheses of Two Pheromone Components of the Fall Webworm Moth, 2010, J. Org. Chem.
- Asymmetric Total Synthesis of (-)-Awajanomycin, 2009, Org. Lett.
- Asymmetric Syntheses and Wnt Signal Inhibitory Activity of Melleumin A and Four Analogues of Melleumins A, B ,2009, Chem. Asian J.
- Enantioselective Synthesis of the Broadly Acting Feeding Deterrent (R)-Ypaoamide ,2009, J. Org. Chem.
- One-pot Cross-coupling of N-Acyl N,O-Acetals with α,β-Unsaturated Compounds, 2009, Chem. Commun.
- Text Book "Organic synthesis", 2004 ,Higher Education Press
- "Organic Name Reactions, Reagents and Rules" (chief editor), 2008, Chemistry Industry Press
- "Asymmetric Synthesis of Five-Membered Ring Heterocycles", 2009, In “Asymmetric Synthesis of Nitrogen Heterocycles” , J. Royer ed. Wiley-VCH
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