Herein, we demonstrate that a very familiar, yet underutilized, physical parameter-gas pressure-can serve as signal readout for highly sensitive bioanalysis. Integration of a catalyzed gas-generation reaction with a molecular recognition component leads to significant pressure changes, which can be measured with high sensitivity using a low-cost and portable pressure meter. This new signaling strategy opens up a new way for simple, portable, yet highly sensitive biomedical analysis in a variety of settings.

http://onlinelibrary.wiley.com/doi/10.1002/anie.201503963/epdf