首页 > 新闻公告 > CEM研究国际动态 CEM研究国际动态
Oxidative [4+2] annulation of styrenes with alkynes under external-oxidant-free conditions

The sequenced Diels–Alder/oxidation reaction represents a powerful route for the construction of aromatic compounds in organic synthesis. The oxidative Diels–Alder reaction with H2 evolution would be a more ideal approach that can avoid the additional oxidation procedure and stoichiometric oxidant. Herein, an oxidative [4 + 2] annulation reaction of styrene derivatives with electron-rich dienophiles accompanying the H2 generation has been developed by using the synergistic merger of photoredox and cobaloxime catalyst. With respect to atom and step-economy ideals, this dual catalytic system enables the formation of high-value molecules from feedstock chemicals in a single step under room temperature.

https://www.nature.com/articles/s41467-018-03534-z

发布日期:2018/04/02 发布者:网站管理员 点击数: